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Various natural antioxidant compounds, such as polyphenols (e.g., epigallocatechin-3-gallate, quercetin, resveratrol) and carotenoids (e.g., lutein, zeaxanthin), have demonstrated potential in reducing oxidative stress and improving retinal health in DR models

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FIGURE 3 3.1.3.1 The Xc-/GSH/GPX4 pathway Inhibition of system Xc and glutathione peroxidase 4 (GPX4) expression leads to insufficient GSH synthesis, resulting in excessive lipid peroxidation and ROS accumulation in the intracellular space

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Hence, the recycling of GSSG must play an important role in maintenance of intracellular GSH levels from the oocyte to the two-cell stage